Kevin Marsh

A library of functional recombinant cell-surface and secreted P. falciparum merozoite proteins.Crosnier, C. Wanaguru, M. McDade, B. Osier, F. H. Marsh, K. Rayner, J. C. Wright, G. J.
Mol Cell Proteomics, (2013). 12:3976-86

Breadth of anti-merozoite antibody responses is associated with the genetic diversity of asymptomatic Plasmodium falciparum infections and protection against clinical malaria.Rono, J. Osier, F. H. Olsson, D. Montgomery, S. Mhoja, L. Rooth, I. Marsh, K. Farnert, A.
Clin Infect Dis, (2013). 57:1409-16

Peripheral blood monocyte-to-lymphocyte ratio at study enrollment predicts efficacy of the RTS,S malaria vaccine: analysis of pooled phase II clinical trial data.Warimwe, G. M. Fletcher, H. A. Olotu, A. Agnandji, S. T. Hill, A. V. Marsh, K. Bejon, P.
BMC Med, (2013). 11:184

Plasmodium falciparum var gene expression homogeneity as a marker of the host-parasite relationship under different levels of naturally acquired immunity to malaria.Warimwe, G. M. Recker, M. Kiragu, E. W. Buckee, C. O. Wambua, J. Musyoki, J. N. Marsh, K. Bull, P. C.
PLoS One, (2013). 8:e70467

Analysis of antibodies to newly described Plasmodium falciparum merozoite antigens supports MSPDBL2 as a predicted target of naturally acquired immunity.Tetteh, K. K. Osier, F. H. Salanti, A. Kamuyu, G. Drought, L. Failly, M. Martin, C. Marsh, K. Conway, D. J.
Infect Immun, (2013). 81:3835-42

Antibodies to polymorphic invasion-inhibitory and non-Inhibitory epitopes of Plasmodium falciparum apical membrane antigen 1 in human malaria.Mugyenyi, C. K. Elliott, S. R. McCallum, F. J. Anders, R. F. Marsh, K. Beeson, J. G.
PLoS One, (2013). 8:e68304

A threshold concentration of anti-merozoite antibodies is required for protection from clinical episodes of malaria.Murungi, L. M. Kamuyu, G. Lowe, B. Bejon, P. Theisen, M. Kinyanjui, S. M. Marsh, K. Osier, F. H.
Vaccine, (2013). 31:3936-42

Erythrocyte-binding antigens of Plasmodium falciparum are targets of human inhibitory antibodies and function to evade naturally acquired immunity.Persson, K. E. Fowkes, F. J. McCallum, F. J. Gicheru, N. Reiling, L. Richards, J. S. Wilson, D. W. Lopaticki, S. Cowman, A. F. Marsh, K. Beeson, J. G.
J Immunol, (2013). 191:785-94

Imputation-based meta-analysis of severe malaria in three African populations.Band, G. Le, Q. S. Jostins, L. Pirinen, M. Kivinen, K. Jallow, M. Sisay-Joof, F. Bojang, K. Pinder, M. Sirugo, G. Conway, D. J. Nyirongo, V. Kachala, D. Molyneux, M. Taylor, T. Ndila, C. Peshu, N. Marsh, K. Williams, T. N. Alcock, D. Andrews, R. Edkins, S. Gray, E. Hubbart, C. Jeffreys, A. Rowlands, K. Schuldt, K. Clark, T. G. Small, K. S. Teo, Y. Y. Kwiatkowski, D. P. Rockett, K. A. Barrett, J. C. Spencer, C. C. Malaria Genomic Epidemiology, Network
PLoS Genet, (2013). 9:e1003509

Four-year efficacy of RTS,S/AS01E and its interaction with malaria exposure.Olotu, A. Fegan, G. Wambua, J. Nyangweso, G. Awuondo, K. O. Leach, A. Lievens, M. Leboulleux, D. Njuguna, P. Peshu, N. Marsh, K. Bejon, P.
N Engl J Med, (2013). 368:1111-20

The ratio of monocytes to lymphocytes in peripheral blood correlates with increased susceptibility to clinical malaria in Kenyan children.Warimwe, G. M. Murungi, L. M. Kamuyu, G. Nyangweso, G. M. Wambua, J. Naranbhai, V. Fletcher, H. A. Hill, A. V. Bejon, P. Osier, F. H. Marsh, K.
PLoS One, (2013). 8:e57320

Plasmodium falciparum infection patterns since birth and risk of severe malaria: a nested case-control study in children on the coast of Kenya.Lundblom, K. Murungi, L. Nyaga, V. Olsson, D. Rono, J. Osier, F. Ogada, E. Montgomery, S. Scott, J. A. Marsh, K. Farnert, A.
PLoS One, (2013). 8:e56032

Phenotypic and functional profiling of CD4 T cell compartment in distinct populations of healthy adults with different antigenic exposure.Roetynck, S. Olotu, A. Simam, J. Marsh, K. Stockinger, B. Urban, B. Langhorne, J.
PLoS One, (2013). 8:e55195

Chronic exposure to Plasmodium falciparum is associated with phenotypic evidence of B and T cell exhaustion.Illingworth, J. Butler, N. S. Roetynck, S. Mwacharo, J. Pierce, S. K. Bejon, P. Crompton, P. D. Marsh, K. Ndungu, F. M.
J Immunol, (2013). 190:1038-47

Lack of avidity maturation of merozoite antigen-specific antibodies with increasing exposure to Plasmodium falciparum amongst children and adults exposed to endemic malaria in Kenya.Ibison, F. Olotu, A. Muema, D. M. Mwacharo, J. Ohuma, E. Kimani, D. Marsh, K. Bejon, P. Ndungu, F. M.
PLoS One, (2012). 7:e52939

A phase 3 trial of RTS,S/AS01 malaria vaccine in African infants.Rts, S. Clinical Trials Partnership Agnandji, S. T. Lell, B. Fernandes, J. F. Abossolo, B. P. Methogo, B. G. Kabwende, A. L. Adegnika, A. A. Mordmuller, B. Issifou, S. Kremsner, P. G. Sacarlal, J. Aide, P. Lanaspa, M. Aponte, J. J. Machevo, S. Acacio, S. Bulo, H. Sigauque, B. Macete, E. Alonso, P. Abdulla, S. Salim, N. Minja, R. Mpina, M. Ahmed, S. Ali, A. M. Mtoro, A. T. Hamad, A. S. Mutani, P. Tanner, M. Tinto, H. D'Alessandro, U. Sorgho, H. Valea, I. Bihoun, B. Guiraud, I. Kabore, B. Sombie, O. Guiguemde, R. T. Ouedraogo, J. B. Hamel, M. J. Kariuki, S. Oneko, M. Odero, C. Otieno, K. Awino, N. McMorrow, M. Muturi-Kioi, V. Laserson, K. F. Slutsker, L. Otieno, W. Otieno, L. Otsyula, N. Gondi, S. Otieno, A. Owira, V. Oguk, E. Odongo, G. Woods, J. B. Ogutu, B. Njuguna, P. Chilengi, R. Akoo, P. Kerubo, C. Maingi, C. Lang, T. Olotu, A. Bejon, P. Marsh, K. Mwambingu, G. Owusu-Agyei, S. Asante, K. P. Osei-Kwakye, K. Boahen, O. Dosoo, D. Asante, I. Adjei, G. Kwara, E. Chandramohan, D. Greenwood, B. Lusingu, J. Gesase, S. Malabeja, A. Abdul, O. Mahende, C. Liheluka, E. Malle, L. Lemnge, M. Theander, T. G. Drakeley, C. Ansong, D. Agbenyega, T. Adjei, S. Boateng, H. O. Rettig, T. Bawa, J. Sylverken, J. Sambian, D. Sarfo, A. Agyekum, A. Martinson, F. Hoffman, I. Mvalo, T. Kamthunzi, P. Nkomo, R. Tembo, T. Tegha, G. Tsidya, M. Kilembe, J. Chawinga, C. Ballou, W. R. Cohen, J. Guerra, Y. Jongert, E. Lapierre, D. Leach, A. Lievens, M. Ofori-Anyinam, O. Olivier, A. Vekemans, J. Carter, T. Kaslow, D. Leboulleux, D. Loucq, C. Radford, A. Savarese, B. Schellenberg, D. Sillman, M. Vansadia, P.
N Engl J Med, (2012). 367:2284-95

Targets of antibodies against Plasmodium falciparum-infected erythrocytes in malaria immunity.Chan, J. A. Howell, K. B. Reiling, L. Ataide, R. Mackintosh, C. L. Fowkes, F. J. Petter, M. Chesson, J. M. Langer, C. Warimwe, G. M. Duffy, M. F. Rogerson, S. J. Bull, P. C. Cowman, A. F. Marsh, K. Beeson, J. G.
J Clin Invest, (2012). 122:3227-38

Analysis of Plasmodium falciparum diversity in natural infections by deep sequencing.Manske, M. Miotto, O. Campino, S. Auburn, S. Almagro-Garcia, J. Maslen, G. O'Brien, J. Djimde, A. Doumbo, O. Zongo, I. Ouedraogo, J. B. Michon, P. Mueller, I. Siba, P. Nzila, A. Borrmann, S. Kiara, S. M. Marsh, K. Jiang, H. Su, X. Z. Amaratunga, C. Fairhurst, R. Socheat, D. Nosten, F. Imwong, M. White, N. J. Sanders, M. Anastasi, E. Alcock, D. Drury, E. Oyola, S. Quail, M. A. Turner, D. J. Ruano-Rubio, V. Jyothi, D. Amenga-Etego, L. Hubbart, C. Jeffreys, A. Rowlands, K. Sutherland, C. Roper, C. Mangano, V. Modiano, D. Tan, J. C. Ferdig, M. T. Amambua-Ngwa, A. Conway, D. J. Takala-Harrison, S. Plowe, C. V. Rayner, J. C. Rockett, K. A. Clark, T. G. Newbold, C. I. Berriman, M. MacInnis, B. Kwiatkowski, D. P.
Nature, (2012). 487:375-9

Memory B cells are a more reliable archive for historical antimalarial responses than plasma antibodies in no-longer exposed children.Ndungu, F. M. Olotu, A. Mwacharo, J. Nyonda, M. Apfeld, J. Mramba, L. K. Fegan, G. W. Bejon, P. Marsh, K.
Proc Natl Acad Sci U S A, (2012). 109:8247-52

Naturally acquired immune responses against Plasmodium falciparum sporozoites and liver infection.Offeddu, V. Thathy, V. Marsh, K. Matuschewski, K.
Int J Parasitol, (2012). 42:535-48