Abstract

The population dynamics of hemoglobins A, A(2), F and S in the context of the hemoglobinopathies HbS and alpha-thalassemia in Kenyan infants

Macharia, A. W. Uyoga, S. Ndila, C. Nyutu, G. Makale, J. Tendwa, M. Nyatichi, E. Ojal, J. Atkinson, S. Williams, T. N.
Haematologica. 2019; 104e184-e186

Permanent descriptor

https://doi.org/10.3324/haematol.2018.199596

Few studies have described the dynamics of haemoglobin production in African populations with a high prevalence of haemoglobinopathies. We have used the BioRad Variant ClassicTM HPLC method to document the production patterns of the common haemoglobin variants HbA, HbA2, HbF and HbS, stratified by a+thalassaemia genotype, among 15,301 infants recruited to a study on the Coast of Kenya. Notably, we confirm that HbA2 measurements determined using this instrument are unreliable in HbAS and HbSS subjects. Further, we showed that HbA2 exceeded 4.0%, a level consistent with the presence of a-thalassaemia, in 0.8% of infants of HbAA phenotype who participated in our study. a-thalassaemia, has not been widely reported in the East Africa region and, as such, this finding merits further study.